膜小胞の形態に関するフェーズ・フィールドシミュレーション(OS2-3 先端材料システム,OS2 先端材料システム設計とメゾメカニックス)

概要

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The design of artificial membranes which have characteristics similar to red blood cell attracts attention from the viewpoint of the application to drug delivery system. The stable structure of such vesicle is studied to solve the problem of the minimization of the bending energy described in terms of local curvature, under subsidiary conditions to keep the surrounding volume of the domain surrounded by it and its surface area. In fact, various possible metastable structures of vesicle are expected by theoretical studies and are observed by experiments. In this study, the shape transformation is discussed by means of a phase-field model (PFM), where the field parameter is introduced to distinguish the domain, the inside, itself and outside of vesicle. A history-dependent feature is found in the shape change with change of surface area.
2004-07-20