変形性膝関節症の治療と関節軟骨再生歴史的考察と自己培養骨髄間葉系細胞移植(<特集>骨関節領域における結合組織研究の進歩)

概要

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The capacity of osteoarthritic cartilage for repair is unclear. We reviewed the surgical treatments of osteoarthritic knee joints and discussed the capacity of regeneration in order to assess our results of autologous bone marrow mesenchymal cell (BMMC) transplantation in osteoarthritic knee. BMMCs has a potential to differentiate into bone, cartilage, fat, and muscle. BMMCs can be easily obtained and multiplied without losing their capacity to differentiate into bone and cartilage. To repair human articular cartilage defect, we transplanted autologous BMMCs into articular cartilage defect in osteoarthritic knee. Adherent cells in bone marrow aspirates were culture expanded, embedded in a collagen gel, and transplanted into the articular cartilage defect in the medial femoral condyle and covered with autologous periosteum at the time of the high tibial osteotomy. As early as 5 weeks after transplantation, the defects were covered with white to pink soft tissue, in which metachromasia was partially observed. About 40 weeks after transplantation, the defects were covered with white soft tissue, in which metachromasia was observed in almost all repair tissue. This procedure may offer a new method for repairing injured articular cartilage in human.
日本結合組織学会の論文
2000-09-25