F-0913 軟骨再生過程の粘弾性評価(S44-1 生体材料研究の新展開(1))(S44 生体材料研究の新展開)

概要

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Mechanical properties of regenerated cartilage tissue were measured to evaluate change of visco-elastic properties during cultivation. Indentation test and dynamic visco-elastic measurement were carried out for rabbit articular cartilage inoculated in fibroin sponge. A 1.5mm-diameter porus indentor was used for the indentation test, where time-dependent strain curves were measured under several loading condition. Although amount of permanent deformation is not influenced by cartilage regeneration, the creep-behavior time constants are extended with cultivation days. The dynamic visco-elastic measurement was performed under compressive loading condition. The E' values increase with cultivation days and the peak value and frequency of tan δ shift to a lower amount. It is suggested that changes in time-dependent strain curves and dynamic visco-elastic properties of the regenerated cartilage are caused by synthesis of extracellular matrix and maturation of cultured cartilage tissue.
一般社団法人日本機械学会の論文
2001-08-22