ネコ由来の Isospora bigemina オーシストの豚への感染試験

概要

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Twelve pigs were divided into 2 groups: the 1st group of seven and the 2nd group of five. Each of them was given orally with 1.7×10^6 sporulated Toxoplasma oocysts, which had been isolated from the feces of an unwanted cat and identified as those of Iosopora bigemina. All the pigs were examined for body temperature and symptoms every day. The 2nd group was fed a ration containing 500 ppm sulfamonomethoxine (6-methoxy-4-pyrimidinyl sulfanilamide monohydrate) and 25 ppm pyrimethamine (2, 4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine) for 7 consecutive days before the inoculation of oocysts and the following 58 days. All the pigs of the untreated 1st group showed an increase in body temperature, loss of vigor, anorexia, ocular discharge, coughing, tachypnea, diarrhea and cyanosis. All of them except one which was killed for pathological examination on the 7th day after inoculation died some time between the 9th and 15th day after inoculation. Histological examination of the 1st group revealed necrotic foci in some visceral organs, including lymph nodes and intestine, and encephalitis and inflammatory edema in both lungs. Suoh lesions as these were seen in no pigs of the 2nd group. Toxoplasma was detected from the pigs of the 1st group, but not from these of the 2nd group, and identified by Giemsa's staining and the mouse inoculation test.
社団法人日本獣医学会の論文
1974-12-25