分子間相互作用ネットワークのモデル化(<小特集>ポストゲノムにおけるバイオシステムシミュレーション : 生命システム現象の包括的な理解に向かって)

概要

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How to represent molecular interactions is the essential problem for the computational analysis and the simulation of life. We have constructed PATHWAY database under the KEGG project for the purpose of the graphical display of the molecular networks, LIGAND and BRITE databases for its backend to store detailed informations of the interactions. Here we compare the network model utilized by these databases to models used in other efforts such as the metabolic map of the Boehringer Mannheim and Kohn's human cell cycle map to discuss the best way of the pathway representation for the future simulations of life. We believe the pathway computation ability and the simplicity of the net work representation are the advantage of our database. For the future simulations, we propose a concept of the general biological molecular relations and introduce some experimental works using Petri net.
日本シミュレーション学会の論文
2001-06-15