静脈注射用コンドロイチン硫酸鉄コロイドについて(第5報) : ^3H標識コンドロイチン硫酸鉄コロイドのマウス投与後における^3Hの体内分布

概要

論文の詳細を見る
Following previous experiment on the fate of iron-chondroitin sulfate colloid using ^<59>Fe-labeled compound, sodium chondroitin sulfate labeled with tritium was synthesized in order to examine its fate in vivo. Using this ^3H-labeled compound, tritiated iron chondroitin sulfate was synthesized, this compound was given as an intravenous injection to normal male mice, and distribution and excretion of tritium were examined. The result of this experiment was comparatively examined with the result of administration of ^<59>Fe chondroitinsulfate. Chondroitinsulfuric acid in the parenteral solution used here was present in two kinds ; one bound with iron colloid and the other not. By assuming that the former is phagocytized in reticuloendothelial system with the iron colloid but the latter is not phagocytized much in the reticuloendothelial system, biological distribution and excretion of ^<59>Fe and ^3H were explained well. Quantitative analysis was made on a part of these results.
公益社団法人日本薬学会の論文
1970-06-25