懸濁製剤の研究(第4報) : CMCおよびMC希薄水溶液粘度と硫酸バリウム粒子の沈降

概要

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It was proved that the nature of the dilute solutions of carboxymethylcellulose and methylcellulose differed markedly in concentrations above and below the minimum point which appears in the reduced viscosity-concentration curves of these solutions. The fact was proved through the examination of temperature dependency of viscosity and of sedimentation rate of barium sulfate granules in these solutions. A equation with better approximation was obtained for carboxymethylcellulose by the addition of the first order term of the concentration to Fuoss' equation As a result of measuring the sedimentation rate of barium sulfate in these solutions, it was learned that sedimentation occurred in three steps periodically, and parameters corresponding to its initial and median periods were calculated. Effect of carboxymethylcellulose and methylcellulose on the sedimentation rate was found to be qualitatively as well as quantitatively different.
公益社団法人日本薬学会の論文
1966-11-25