静脈注射用コンドロイチン硫酸鉄コロイドについて(第6報) : ^<59>Feおよび^3H標識デキストラン鉄コロイドのマウス投与後における^<59>Feおよび^3Hの体内分布

概要

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In order to examine the difference in biological fate of iron from iron hydroxide colloid for injection containing a variety of stabilizer, iron-dextran colloid labeled with ^<59>Fe and ^3H was injected intravenously into normal male mice and systemic distribution of ^<59>Fe and ^3H was examined. The result obtained was comparatively examined with that obtained by the injection of iron chondroitinsulfate colloid labeled with ^<59>Fe and ^3H, and the following observations were made. 1) The rate of disappearance of from blood and phagocytized in the reticuloendothelial cells depends on the kind of stabilizer used, and the rate of disappearance is faster in iron chondroitinsulfate than iron-dextran colloid. 2) Utilization of iron as hemoglobin iron and incorporated into red blood cells is not affected by the kind of stabilizer present. 3) Relative distribution of ^3H and ^<59>Fe in various organs is approximately the same from both kinds of colloid but some organs showed a difference considered to be due to the difference in the metabolism of stabilizer liberated after a long time.
公益社団法人日本薬学会の論文
1970-12-25