リノール酸アミド誘導体のニワトリおよびマウスにおけるコレステロール低下作用

概要

論文の詳細を見る
Cholesterol-lowering effects of two amide derivatives of linoleic acid, N-cyclohexyl linoleamide (CHLA) and N-(α-methylbenzyl) linoleamide (MBLA), were studied in chicken and mice. (1) In normocholesteremic chickens, CHLA and MBLA showed a slight cholesterol-lowering effect at a dose of 1.0%, but they did not show any cholesterol-lowering effect in normocholesteremic mice at a dose of up to 0.2%. (2) By the addition of 0.2% of CHLA or MBLA to the cholesterol diet in chickens and in mice, the elevation of serum cholesterol levels was markedly depressed and the content of cholesterol and total lipids in the liver was also depressed. The effectiveness of CHLA and MBLA in chickens was almost the same, and was about 5-fold of that of β-sitosterol. In mice, the potency of MBLA was about twice that of CHLA, and about 10 times that of β-sitosterol. (3) CHLA and MBLA showed no marked effect on hypercholesterolemia induced by β-estradiol in chickens or by Triton WR 1339 in mice.
公益社団法人日本薬学会の論文
1969-06-25