実験糖尿病におよぼす含硫化合物の影響(第2報)) : インシュリン遊離または作用時の血糖と血液酸可溶性SH, S-S基量変動との関連性

概要

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1) S-S compounds such as oxidized glutathion, oxidized 2-mercaptopropionylglycine, and cystine were administered to normal and alloxan-diabetic rabbits, and the variations of blood sugar value, and of acid-soluble SH and S-S groups in the blood were observed for one week. Compounds which accelerate the liberation of insulin and compounds which antagonize the insulin action were also examined in the same manner. 2) Administraion of S-S compound to the normal rabbit resulted in no change of the blood sugar amount, decrease of SH groups and increase of S-S groups which recovered a normal level after 24 hr ; administration of S-S compounds to alloxan diabetic rabbits decreased SH groups which did not recover a normal level even after 24 hr. Blood sugar level tended to rise with the repetition of the administration. 3) compounds which have insulin action and compounds which accelerate the liberation of insulin by stimulating the pancreatic β cells, increase the S-S groups and decrease or do not affect the SH groups in normal rabbits (insulin, glucose, alloxan). In diabetes, both SH and S-S groups increase (insulin, R-SH). 4) Compounds which antagonize insulin action tend to decrease S-S groups (adrenalin, glucagon).
公益社団法人日本薬学会の論文
1969-02-25