Arylpropynylether誘導体のポーラログラフィー(第2報) : ポーラログラフィーによる製剤中の2,4,5-Trichlorophenyl 3-Iodo-2-propynyl Etherおよび2,4,5-Trichlorophenyl 2-Propynyl Etherの定量

概要

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Polarographic determination was carried out on 2,4,5-trichlorophenyl 3-iodo-2-propynyl ether (TCPI) in pharmaceutical preparation, and simultaneous determination of TCPI and 2,4,5-trichlorophenyl 2-propynyl ether (TCPH) in their mixture. Under the present experimental conditions, TCPI is polarographically active but TCPH is not. For the determination of TCPI in pharmaceutical preparation, the sample is dissolved in or diluted with ethanol, the second wave in the polarogram is measured, and calculation made by the standard addition method. Simultaneous determination of TCPI and TCPH is made by measuring the second wave in the polarogram to obtain the amount (A) of TCPI, deiodination-reduction is carried out with sodium borohydride, copper salt is formed by the use of the Ilosvay reagent, which is decomposed with ethanolhydrochloric acid mixture, and polarogram of the decomposed solution is measured. The sum (B) of TCPI and TCPH is calculated from this measurement, and the amount (C) of TCPH is calculated from (B)-(A)=(C).
公益社団法人日本薬学会の論文
1968-03-25