医薬品のボーラログラフィー的研究(第2報) : Anethole Trithioneのボーラログラフィー

概要

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AC and DC polarographic behavior of anethole-trithione [5-(p-methoxyphenyl)-1,2-dithia-4-cyclopentene-3-thione], widely employed as a cholegogic, was examined, using hydrochloric acid-pyridine as the supporting electrolyte. Controlled potential electrolysis was carried out and an electrode reaction mechanism was proposed. Anethole-trithione shows a two-step reduction wave in both AC and DC polarography, and the first wave shows a linear increase in proportion to the concentration. Variation of these peak potentials or half-wave potentials by concentration is such that it can be neglected. The AC peak current varies according to the amount of dioxan and hydrochloric acid-pyridine in the electrolytic solution and with the period of standing. Then DC polarogram of the electrolytic solution submitted to controlled potential electrolysis at -0.60 V exhibits the oxidation-reduction wave as the first wave, and that electrolyzed at -0.85 V shows the presence of a mercaptide and mercury sulfide, suggesting that the first wave is that of a reversible reaction from 1,2-dithiol bond to thiol, and the second wave is that of a reduction of the 1,2-dithiol-3-thione bond, resulting in the formation of a thiol and a sulfur ion.
公益社団法人日本薬学会の論文
1968-11-25