Arylpropynylether誘導体のポーラログラフィー(第1報) : 2,4-Dichlorophenyl 3-iodo-2-propynyl etherおよび2,4,5-Trichlorophenyl 3-iodo-2-propynyl etherのポーラログラフィー

概要

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The polarographic nature of 2,4-dichlorophenyl 3-iodo-2-propynyl ether (DCPI) and 2,4,5-trichlorophenyl 3-iodo-2-propynyl ether (TCPI), used as good anti-trychophyton agents, was examined. Three reduction waves were observed in DCPI and two in TCPI. First and second waves of DCPI and first wave of TCPI were small, there was no transition of the half-wave potentials by pH, and the wave height did not make proportional increase with the concentration. From contact with metallic mercury, electrocapillary curves, and from polarography with rotated platinum electrode, the first wave in both compounds was considered to be the adsorption wave. The 3rd wave of DCPI and 2nd wave of TCPI showed linear increase proportional with the concentration, and they were found to be the reduction wave due to deiodination from the fact that the reduction products by electrolysis at controlled potential were 2,4-dichlorophenyl 2-propynyl ether from DCPI and 2,4,5-trichlorophenyl 2-propynyl ether from TCPI.
公益社団法人日本薬学会の論文
1966-11-25