製剤からの薬物溶出のシミュレーション(第1報) : 錠剤および粉末の溶解速度

概要

論文の詳細を見る
Dissolution rates of various tablets and powder with various particle size distribution were measured by using the rotary basket method adopted in USP XIX (1975). Simulation technique using a computer can be applied to the dissolution measurement of these samples, the amount of solute dissolved was calculated step by step on the basis of the Nernst-Brunner's dissolution model, and a good agreement was found between the calculated and experimental amount of dissolution for various tablets and powder. The tablet was handled as an iso-volume sphere, poly-dispersed powder was handled as a gathering of mono-dispersed sphere, and the observed dissolution rate constant (k (obs.)) agreed well with the dissolution rate constant (k (simu.)) obtained by the simulation technique. The effect of tablet size, initial solute concentration in the dissolution medium, and the rotating speed on the dissolution rate constant (k (simu.)) or dissolution rate was tested. k (simu.) decreased with an increase in tablet size, dissolution rate decreased with an increase in initial solute concentration, and k (simu.) increased linearly with an increase in rotating speed. The proposed theory and simulation technique are useful for the analysis of the dissolution of tablets or powder with various particle size distribution.
公益社団法人日本薬学会の論文
1977-07-25