製剤からの薬物溶出のシミュレーション(第5報)膜の分配率
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概要
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To date, the apparent membrane partition coefficient (P_a) has been obtained by an apparent decrease of concentration in a membrane-solution system. However, a part of the solute molecules absorbed by the membrane seems to be in the immobile state because the molecules are tightly restricted by the membrane component. The partition coefficient which is related to the diffusion must be defined by the mobile solute only. We may call the partition coefficient defined by the mobile solute"reversible partition coefficient (P_r)", and the partition coefficient defined by the immobile solute"irreversible partition coefficient (P_<1r>)". The P_r can be obtained by 2 step experiments (absorption of solute by, and release of solute from the membrane). Theories on the P_r of the membrane and the porous membrane are proposed here. Silicone rubber membrane was prepared from the silicone rubber compound (SRC : Shinetsu Kagaku KE-102RTV) and concentration dependence of the P_a and P_r were measured on the SRC-membrane-salicylic acid (SA) solution system. The P_a and P_r values decreased with an increase in SA-concentration and the P_a value approached the P_r value. On the other hand, the P_a and P_r values were measured on the benzene-SA-solution and silicone oil-SA-solution systems and it is clear that the P_a value is nearly equal to the P_r value in the liquid-liquid system. The P_r value of the SRC-membrane is 6 times greater than the P_r value of the silicone oil. The permeation of SA through the SRC-membrane was measured on the SA-solution-memberane-water system, the results were compared with the simulation results carried out on the basis of the theory and technique reported before (Ref. 5 and 6), and good agreements were obtained between them. The experimental results disagreed with the simulation results which were obtained by using the P_a value.
- 社団法人日本薬学会の論文
- 1979-03-25
著者
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