製剤からの薬物溶出のシミュレーション(第4報)ドラッグデリバリーシステムからの溶出 その1
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概要
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The theories of drug release from the pinhole of sphere (System-1) and drug release from the slot of sectoral wedge (System-2) are presented and drug release from System-1 was measured, using a sulfamethxazol (SMX) sphere coated with beeswax. The simulation technique for System-1,using a digital computer can be applied to the dissolution of SMX, the amount of SMX dissolved was calculated step by step on the basis of the Nernst-Brunner's dissolution model, and a good agreement was found between the calculated and measured amount of SMX. The simulation technique for System-2 can be applied to Brooke-Washkuhn experiments and a good agreement was found between the calculated and measured amount of stearic acid from System-2. The proposed theories and simulation techniques are applicable to various drug delivery systems with various geometry and are useful for the selection of the ideal form.
- 社団法人日本薬学会の論文
- 1979-02-25
著者
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