製剤からの薬物溶出のシミュレーション(第3報) : クリームあるいはエマルションからの薬物の溶出

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Drug release from the O/W emulsion was measured by using a drug-release cell. Sample emulsion was prepared by vigorous mixing of a mixture of water, isopropyl myristate, surface-active agent (PBC-31,Nikkol), and salicylic acid (model compound), and the droplet size distribution of sample emulsion was measured by a particle size analyzer (Japan Regulator Co.). The effect of the amount of a surfactant on the release percentage in the liquid phase was tested by changing its amount from 0.2 to 2%. Simulation technique using a computer can be applied to the measurement of drug penetration at the droplet surface, release percentage in the liquid phase was calculated step by step on the basis of the proposed model, and a good agreement was found between the calculated and experimental release-percentages at the measured points with various lapsed time. Poly-dispersed droplets were handled as a gathering of monodispersed sphere, drug migration in the droplet was handled as the radial diffusion, and theoretically reasonable results were obtained from the model calculation that the drug release from the smaller droplet is faster than from larger droplets and the concentration in droplets near the surface is lower than that in the central part. The special resistance (X) of drug penetration at the droplet surface, which may be attributed to the presence of a surfactant film, was obtained and this resistance may be useful for the assessment of surfactants. The proposed theory and simulation technique are useful for the analysis of the drug-release from an emulsion or a cream.
社団法人日本薬学会の論文
1977-07-25

製剤からの薬物溶出のシミュレーション(第3報) : クリームあるいはエマルションからの薬物の溶出

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