製剤からの薬物溶出のシミュレーション(第7報)クリーム基剤からの薬物の溶出

概要

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Salicylic acid (SA) release from the model cream base, density of oily phase, partition coefficient of SA between the oily and water phase (P_d), diffusion coefficient of SA in the oily phase and in the membrane (Fuji film Co. FR-40), and particle size distribution of model cream were measured and the ratio (R-value) between the percent release of SA and the theoretically releasable amount of SA, which can be calculated from the volume and partition coefficients of drug, membrane, and receptor phase were compared with the R-value of emulsion quoted from Ref. 1). The obstruction effect of droplet on drug release was also proved by the decrease in R-value with an increase in the volume fraction (VF) of the oily phase. The obstruction effect in the cream is greater than that in the emulsion. X-value of cream base, which is the special resistance of drug penetration at the droplet surface, was 1380 times greater than the X-value of emulsion. The percent release in the cream was determined by the SA amount in the continuous phase, because the SA in the droplet cannot be released practically.
社団法人日本薬学会の論文
1979-11-25