エタノール脂肪肝における肝臓成分と薬物代謝酵素系に対するジブチルヒドロキシトルエンの影響

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Effect of pretreatment of female rats with dibutylhydroxytoluene (BHT) (200 mg/kg, daily for 5 days on lipids and drug metabolizing enzyme activities in fatty liver induced by ethanol (6 g/kg) were investigated. Ethanol-induced accumulation of hepatic triglyceride was not inhibited by a 5-day pretreatment with BHT. Content of phospholipid in microsomes and mitochondria were increased by BHT treatment alone, but no change by ethanol alone. Ethanol treatment markedly enhanced cholesterol content, and the increase with BHT treatment alone was significant, but was less than that with ethanol alone. Contents of cytochrome P-450 and b_5,magnitude of binding spectrum of aniline to cytochrome P-450,and activity of aminopyrine N-demethylase were significantly increased by BHT treatment alone, whereas ethanol markedly enhanced only the activity of aniline hydroxylase. Effect on lipid content and activities of drug metabolizing enzymes by successively given BHT and ethanol was approximately equal to the sum of respective effect by each agent.
社団法人日本薬学会の論文
1974-04-25