ラットにおけるカドミウム, 鉛の組織内濃度, 排泄に及ぼすカドミウム, 鉛同時投与の影響

概要

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After simultaneous administration of cadmium chloride and lead acetate to rats, the tissue concentration and excretion of the metal, as well as cadmium-binding proteins in the liver and kidney supernatant fractions, was examined. 1) Content of cadmium in the liver, kidneys, and bone decreased to a greater extent by the simultaneous treatment with cadmium chloride and lead acetate than by the treatment with cadmium chloride alone. 2) Fecal and biliary excretion of cadmium also decreased by the simultaneous treatment with cadmium chloride and lead acetate, while the content of lead was increased in feces. 3) After treatment with cadmium chloride alone, cadmium in the liver supernatant fraction was present in both positions of low-molecular protein (cadmium-binding protein) and of considerably high-molecular (about 20000-30000) protein fractions. After simultaneous treatment with cadmium chloride and lead acetate, lead was concentrated markedly in the low-molecular protein fraction instead of cadmium, although lead was bound little to that position after treatment with lead acetate alone. In the kidney supernatant fractions, cadmium was present in the low-molecular fraction, and this localization was not affected by simultaneous treatment.
公益社団法人日本薬学会の論文
1978-08-25