肝部分切除ラットにおける肝臓成分とミクロゾーム薬物代謝酵素系におよぼすジフェニールヒダントインの影響

概要

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The effects of diphenylhydantoin (DPH) treatment on the liver constituents and drug metabolizing enzyme activities in intact, sham-operated, and partially hepatectomized rats wereinvestigated. The amounts of water, total lipids, and triglyceride were increased by partial hepatectomy, while the contents of total lipids and triglyceride were decreased by sham-operation alone. Partial hepatectomy decreased the contents of microsomal protein and cytochrome P-450,and aminopyrine demethylase and aniline hydroxylase activities were decreased, whereas aminopyrine demethylase activity was decreased also in sham-operated group. In partially hepatectomized rats, treatment with diphenylhydantoin significantly increased the contents of cytochrome P-450 and b_5,and activities of aminopyrine demethylase and aniline hydroxylase. In contrast, it decreased the contents of total lipids and triglyceride. However, treatment with diphenylhydantoin did not affect the contents of lipids, protein, and cytochrome P-450 and b_5,and enzyme activities in intact and sham-operated rats.
公益社団法人日本薬学会の論文
1974-04-25