ひ素化合物投与ラット, 家兎におけるひ素の体内分布, 排泄について

概要

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Distribution of arsenic in blood and tissues, and excretion of arsenic in feces and urine after an oral administration of arsenic trioxide (29 mg/kg) or methylarsine sulfide (36 mg/kg) were examined in rats and rabbits. Blood level of arsenic in rats reached the maximum 3 days after a single administration of arsenic trioxide, and decreased at a slow biological half-life of 60 days, but blood concentration of arsenic in rabbits was about 1/80 of that in rats 24 hr after dosing. Distribution of arsenic in rat tissues attained the maximum 2 days, but its content was only 1% of the administered dose. Excretion of arsenic in rat feces was 68.6% during the first 4 days and a trace amount of arsenic was detected in bile. Fecal excretion of arsenic in rabbits was 62.9% and 36.2% during 7 days, respectively, when arsenic trioxide and methylarsine sulfide were given. On the other hand, urinary excretion of arsenic in the rat was only 1.8% of the dose during 30 days after arsenic trioxide administration, but the level of arsenic in rabbit urine was 5.5% and 18.2%, respectively, during 7 days after arsenic trioxide and methylarsine sulfide treatment.
公益社団法人日本薬学会の論文
1974-10-31