高速液体クロマトグラフ法による医薬品の分析(第7報)ボタン皮中のペオノールの定量

概要

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A rapid method for determining paeonol in Moutan Cortex ("Mudanpi"-root bark of Paeonia moutan) was established by high-speed liquid chromatography. Paeonol was separated in a 25 cm column of Zorbax CN, using a Shimadzu-Du Pont Model LC-2 liquid chromatograph, with 50% acetonitrile as the desorption solution. Separation was completed within 7 min. Paeonol in Moutan Cortex was extracted with methanol and the extract was injected directly into the column. Paeonol content was estimated from previously prepared calibration curves based on standard paeonol. At 275 nm, the precision of the determination was about ±1% and the detection limit was about 2 ng (S/N ratio, 3). It was concluded that this method is useful for the evaluation of Moutan Cortex.
公益社団法人日本薬学会の論文
1980-02-25