抗Virus化合物(第14報)Alkoxy-acetophenoneおよび-benzalacetone N-置換Amidinohydrazone類の活性

概要

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N-Substituted amidinohydrazone (AH) of alkoxyacetophenones and alkoxybenzalacetones (BZ) were synthesized and examined mainly for activities against influenza viruses. These AHs exhibited 50% inhibitory concentrations of 1.4-90 μg/ml (Index 10-159) and 50% virucidal concentrations of 0.001-0.7 μg/ml (Index 10^3-10^6) against influenza viruses such as A_0/PR-8,A_1/FM-1,A_1/Fukuoka, A_2/Adachi, A_2/Aichi, B/Lee, B/Kagoshima and Horse/Miami in the chorio-allantoic membrane culture. N-Methyl AHs of p-decyloxy BZ and m-methoxy-p-decyloxy BZ showed excellent inhibitory activities, and N-methyl AHs of p-decyloxy BZ and m-methoxy-p-octyloxy BZ remarkable virucidal activities. It is inferred that introduction of methyl group on amidino moiety of AHs increases the activity and decreases the toxicity against host-cell. These AHs showed minimum inhibitory concentration of 0.78-100 μg/ml against mycoplasma gallisepticum, fungi and bacteria.
社団法人日本薬学会の論文
1984-08-25