腎結紮ラットにおけるセファゾリンの胆汁中排泄

概要

論文の詳細を見る
To study the influence of renal ligation on the kinetics of biliary excretion, cefazolin (CEZ) was i.v. administered to the renal-ligated rats and the sham-operated rats. Plasma concentration of CEZ was significantly higher in the renal-ligated rats than in the sham-operated rats. T_1/_2β in rats without renal function increased approximately 8 times that in rats with normal kidney function, while the plasma clearance decreased to a similar extent. In the renal-ligated rats, the amount of CEZ excreted into the 6-h bile was 61% of dose which was about 4.5 times that in the sham-operated rats. The apparent biliary clearance also increased more significantly than that in the sham-operated rats. A significant reduction of plasma protein binding of CEZ by renal ligation in vitro, in spite that no changes of albumin concentration was observed. It is suggested that the increase of apparent biliary clearance observed in the renal-ligated rats may be due to the reduction of protein binding. These observations indicated that complete damage of the excretory function of the kidneys may partially be compensated by biliary excretion.
社団法人日本薬学会の論文
1982-12-25