Cefazolin, a New Semisynthetic Cephalosporin Antibiotic. V. Distribution of Cefazolin-^<14>C in Mice and Rats after Parenteral Administration

概要

論文の詳細を見る
To investigate the metabolic fate of cefazolin (CEZ), a new semisynthetic cephalosporin analogue, two kinds of ^<14>C-labeled CEZ were synthesized. The distribution of ^<14>C-labeled CEZ in rats and mice after parenteral administration was studied using whole body autoradiography and liquid scintillation counting. The results of both studies agreed well in many aspects. Very rapid distribution throughout the whole body, except for the brain and fetuses, and complete elimination of the radioactivity in a short term were observed.
公益社団法人日本薬学会の論文
1972-06-25