新β-ラクタム抗生物質ペネム及びカルバペネムに関する研究
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In the research of penems, a versatile intermediate 2-thioxopenam was synthesized, from which many penem derivatives were obtained. The structure-activity relationship analysis of the synthesized penens showed that cyclic amine side chain was most effective one as a substituent of 2-thiopenems. Several carbapenems with the same side chain as penems at 2-position were synthesized, one of the compounds was RS-533. Some effective methods for carbapenem synthesis were also discussed.
- 公益社団法人日本薬学会の論文
- 1987-03-25
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