2種類の溶融シリカキャピラリーカラム付きガスクロマトグラフィーを用いた薬物の検索システム

概要

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Drugs and pesticides (129 compounds) of abuse have been analysed simultaneously by a capillary gas chromatograph with dual fused-silica column having different polarity and retention index data have been compiled for these compounds. By installing two differently coated columns with a split adapter in the same injector and connecting these column ends to flame ionization detectors (FID), the simultaneous gas chromatographic analysis of these compounds was accomplished. Two fused silica columns were CBP-1 and CBP-10 (0.2 mm i.d.×50 m, film thickness 0.25μm). The column temperature increased from 100℃ to 320℃ at 10℃/min, the detector and injector temperature was 280℃. Discriminating power (DP) was 0.993 with combination of two columns (error factor=30). Retrieval system was developed through the use of a retention index library and the program of this system was written with BASIC. A summary of the BASIC program used for retention index calculation and library seach is included. Furthermore, it was possible to estimate the molecular weights and to specify compounds with retention index by using this system.
公益社団法人日本薬学会の論文
1988-06-30