化粧品中の特殊成分分析法に関する研究(第9報)ヘキサクロロフェンの薄層ならびにガスクロマトグラフィーによる定性および定量法

概要

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A method for analysis of hexachlorophene in toilet goods was examined by thin-layer chromatography and gas chromatography. Hexachlorophene was separated from samples by extraction with hexane containing 10% ethanol and followed by column chromatography over DEAE-cellulose. The fraction obtained by elution of the column with a mixture of acetone and hydrochloric acid was submitted to alumina layers containing silver nitrate and silica gel layers. After development with petroleum ether acetic acid (88 : 12) on both layers, phenolic compounds were separated and detected on alumina layers under ultraviolet irradiation and on silica gel layers by spraying with 4-aminoantipyrine reagent. A compound was separated from some phenolic compounds by gas liquid chromatography using a gas chromatograph equipped with a flame ionization detector or an electron capture detector, and a column of SE-30 on Chromosorb G, and the limit of determination was 250 and 1 μg/ml, respectively. This method was found to be sufficiently satisfactory for determination of hexachlorophene in baby powder, cream, soap, shampoo, and hair tonic.
社団法人日本薬学会の論文
1974-10-31