臭化水素の付加反応を利用したエチレンオキサイドの電子捕獲型検出器付ガスクロマトグラフィーによる定量法

概要

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Microanalysis dealing with microgram level of ethyleneoxide (EO) is described. In this method, a florisil column prepared with hydrobromic acid was used as a reaction column to convert EO into ethylenebromohydrine (EBH). Samples, medical devices such as disposable syringe and foods such as pepper, dissolved in ethanol were heated in a water bath at 80°. EO expelled from the ethanol solution with N_2 gas by N_2-bubbling was introduced into the reaction column. EO in an air was collected in a sampling bag and directly introduced into the column by suction from the exit of the column. After EO was introduced, EBH formed in the column was eluted with ether, and the eluate was concentrated. EBH was determined by gas chromatography equipped with an electron capture detector. By this procedure, 0.1 ppm of EO in medical devices and foods, and 0.5 ppm in atmospheric air can be determined at about 3% of coefficients of variation without interference of co-existing organic substances.
公益社団法人日本薬学会の論文
1980-06-30