ISOLATION OF BILOBALIDE AND GINKGOLIDE A FROM GINKGO BILOBA L. SHORTEN THE SLEEPING TIME INDUCED IN MICE BY ANESTHETICS

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概要

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• The leaves of <Ginkgo>___- <biloba>___- L. and aqueous extract from them shortened the sleeping time induced in mice by anesthetics (hexobarbital, α-chloralose and urethane, i.p.). Two characteristic terpenoids in <G.>___- <biloba>___-, bilobalide and ginkgolide A, significantly shortened the sleeping time induced by anesthetics.A toxic substance, 4-O-methylpyridoxine (MPN), responsible for "gin-nan food poisoning" isolated from the seed of <G.>___- <biloba>___-, was not detected from the extract of the leaves of <G.>___- <biloba>___-. Therefore, the Ginkgo biloba extract has no toxicities for MPN.

• 公益社団法人日本薬学会の論文
• 1993-02-15

著者

• 和田 啓爾

  北海道医療大学薬学部

• 和田 啓爾

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 久保田 洋子

  Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University

• 羽賀 正信

  東日本学園大学薬学部

• 羽賀 正信

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University, Nishi-5-chome, Kita-12-

• 佐々木 啓子

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 羽賀 正信

  公立昭和病院

• Haga M

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• Haga Masanobu

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 羽賀 正信

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• 八木 昌明

  Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University

• Wada K

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Health Sciences University Of Ho

• 佐々木 啓子

  北海道医療大学薬学部

• 三浦 憲一

  Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University

• 松本 武

  Biochemical Laboratory, Research Center, Daicel Chemical Industries, LTD.,

• 八木 昌明

  Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido

• 佐々木 啓子

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 三浦 憲一

  Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University

• 松本 武

  Biochemical Laboratory Research Center Daicel Chemical Industries Ltd.

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