Bidirectional Effects of Hypergravity on the Cell Growth and Differentiated Functions of Osteoblast-Like ROS17/2.8 Cells
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概要
- 論文の詳細を見る
A low level of hypergravity (1.5-2.0 G) stimulated the proliferation of ROS17/2.8 cells, whereas it inhibited the differentiated functions of alkaline phosphatase activity and osteocalcin synthesis. These results were just the opposite of our results obtained when the cells were exposed to a high level of hypergravity (40-80 G) : inhibition of cell growth and the stimulation of the differentiated functions. The direction of change in the cAMP contents of the cells was also reversed, with a low level of hypergravity causing a decrease in the cAMP content and a high level of hypergravity an increase in it. Therefore, bidirectional effects of hypergravity on the growth and differentiated functions exist in ROS17/2.8 cells according to the magnitude of the hypergravity.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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Endo H
Teikyo Univ. Kanagawa Jpn
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Endo Hiroyoshi
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Negishi Yoichi
Department of Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and L
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Negishi Yoichi
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Kishi Koichiro
Departments Of Pharmacology Jichi Medical School
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KAWASHIMA Kohtaro
Department of Physiological Chemiustry, Faculty of Pharmaceutical Sciences, Teikyo University
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Kawashima K
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Furutsu Mio
Biochemistry Laboratory College Of Pharmacy Nihon University
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Kawashima Kohtaro
Department Of Physiological Chemiustry Faculty Of Pharmaceutical Sciences Teikyo University
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Negishi Yoichi
Department of Chemical Engineering, Yokohama National University
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Kawashima Kohtaro
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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