Effects of KCA-012 on Bone Metabolism in Organ Culture
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概要
- 論文の詳細を見る
3, 9-Dihydroxy-<I>5H</I>-benzofuro[3, 2-c]quinoline-6-one (KCA-012), the chemical structure of which is closely similar to that of the phytoestrogen coumestrol, inhibited parathyroid hormone-, 1α, 25-dihydroxyvitamin D<SUB>3</SUB>- and prostaglandin E<SUB>2</SUB>-induced bone resorption of cultured fetal rat bones. KCA-012 also increased the calcium content of 9-day chick embryonic femur cultured in vitro. KCA-012 did not show any estrogenic activity as determined by an increase in the uterine weight of ovariectomized rats, whereas coumestrol did. These results indicate that KCA-012 has no estrogenic activity and has unique effects of inhibiting bone resorption and stimulating bone mineralization.
- 社団法人 日本薬理学会の論文
- 1995-02-01
著者
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Endo Hiroyoshi
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Nagata Hideo
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Kishi Koichiro
Departments Of Pharmacology Jichi Medical School
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UJIIE Arao
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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Ujiie Arao
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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KAWASHIMA Kohtaro
Department of Physiological Chemiustry, Faculty of Pharmaceutical Sciences, Teikyo University
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Kawashima K
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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TSUTSUMI Naoyuki
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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Kawashima Kohtaro
Department Of Physiological Chemiustry Faculty Of Pharmaceutical Sciences Teikyo University
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Tsutsumi Naoyuki
Central Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Kawashima Kohtaro
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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