Selective Activation of Diaphyseal Chondrocytes by Parathyroid Hormone, Calcitonin and N<SUP>6</SUP>, O<SUP>2</SUP>-Dibutyryl Adenosine 3, 5-Cyclic Monophosphoric Acid in Proteoglycan Synthesis of Chick Embryonic Femur Cultivated <I>In Vitro</I>
スポンサーリンク
概要
- 論文の詳細を見る
We have found that the developmental stage of chondrocytes in the chick embryo femur is sensitive to the action of PTH, CT and dibutyryl cyclic AMP in stimulating proteoglycan synthesis as estimated by the incorporation of radioactive inorganic sulfate. PTH treatment of the cartilage resulted in dramatic stimulation of the proteoglycan synthesis in the diaphysis, which is composed of rather old non-dividing hypertrophied chondrocytes with much lower proteoglycan-synthesizing activity than younger dividing cells in the epiphysis and metaphysis. No or slight stimulation was observed the epiphysis and metaphysis. Dibutyryl cyclic AMP produced much the same effect. CT also stimulated the proteoglycan synthesis only in the diaphysis but the stimulation was less potent (133% of control) than PTH (650% of control) or dibutyryl cyclic AMP (625% of control). The hormones and dibutyryl cyclic AMP, therefore, seem to activate the proteoglycan synthesis specifically in rather old chondrocytes of the diaphysis. A synergistic effect of PTH and CT suggesting a different stimulating mechanism was observed in the diaphysis.
- 社団法人 日本内分泌学会の論文
著者
-
Endo Hiroyoshi
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
-
Kawashima Kohtaro
Department Of Physiological Chemiustry Faculty Of Pharmaceutical Sciences Teikyo University
-
IWATA SHINJIRO
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
-
Kawashima Kohtaro
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
関連論文
- Oral dimethyl sulfoxide for systemic amyloid A amyloidosis complication in chronic inflammatory disease : a retrospective patient chart review
- Microgravity generated by space flight has little effect on the growth and development of chick embryonic bone
- Effects of KCA-012 on Bone Metabolism in Organ Culture
- Stimulative Effect of High-level Hypergravity on Differentiated Functions of Osteoblast-like Cells
- Bidirectional Effects of Hypergravity on the Cell Growth and Differentiated Functions of Osteoblast-Like ROS17/2.8 Cells
- Improvement by Exogenous Cyclic AMP of Hereditary Vasopressin-Resistant Diuresis in Mice with Normal Adenyl Cyclase System of the Kidney Cells
- Level of Newly Synthesized Cyclic AMP in the Isolated Rat Kidney Cells and Its Changes by Vasopressin
- Effect of Hydrocortisone on Hela Cells with Special Reference to the RNA Metabolism
- Direct Regulation of Bone Resorption of Chick Embryonic Femur in Organ Culture by the Change of Calcium or Phosphate ion Concentration in the Medium
- Selective Activation of Diaphyseal Chondrocytes by Parathyroid Hormone, Calcitonin and N6, O2-Dibutyryl Adenosine 3, 5-Cyclic Monophosphoric Acid in Proteoglycan Synthesis of Chick Embryonic Femur Cultivated In Vitro
- Growth Stimulative Effect of Parathyroid Hormone, Calcitonin and N6, O2-Dibutyryl Adenosine 3, 5-Cyclic Monophosphorie Acid on Chick Embryonic Cartilage Cultivated in a Chemically Defined Medium
- Absence of Response of Chick Embryonic Limb to the Growth Stimulatory Effect of Parathyroid Hormone In Vitro after Exposure to 6-Aminonicotinamide In Ovo
- High prevalence of Sulfadoxine/pyrimethamine resistance alleles in Plasmodium falciparum parasites from Bangladesh
- Synthesis of Epidermal Specific Proteins Selectively Stimulated by Hydrocortisone in the Chick Embryonic Skin Growing in a Chemically Defined Medium
- Effect of Hormones on the Chondroitin Sulfate Metabolism of Chick Embryo Femora Growing in Vitro. 2. Differential Effect of Cortisol on Chondroitin Sulfate Synthesis in the Cartilagenous Bones Growing in Various Natural and Synthetic Media
- Effects of KCA-098 on Bone Metabolism: Comparison with Those of Ipriflavone.