Virus Inactivation in Superoxide Dismutase Preparations by Ultraviolet Light Irradiation
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概要
- 論文の詳細を見る
Viral inactivation in superoxide dismutase (SOD) derived from human red cells was carried out by ultraviolet light C (UVC) irradiation. With 400J/m^2 UVC irradiation, the titer of canine parvovirus (CPV, a nonenveloped virus), M13 bacteriophage (M13,a nonenveloped phage) and vesicular stomatitis virus (VSV, an enveloped virus), which were spiked into SOD solution, were reduced by >4.6log_<10> (detection limit), 7.0log_<10> and 6.2log_<10>, respectively. The SOD activity was maintained and the band pattern of SOD on an electrophoresis gel was not changed even by 1000J/m^2 UVC irradiation. These results indicate that UVC irradiation is a promising method for the inactivation of both enveloped and nonenveloped viruses in SOD preparations while maintaining its activity.
- 社団法人日本薬学会の論文
- 1998-06-15
著者
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Ikebuchi Kenji
Hokkaido Red Cross Center, Japanese Red Cross
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Sekiguchi Sadayoshi
Hokkaido Red Cross Center, Japanese Red Cross
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ABE hideki
Hokkaido Red Cross, Blood Center
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IKEBUCHI Kenji
Tokyo Medical University
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Abe H
Hokkaido Red Cross Blood Center
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Abe Hideki
早稲田大学理工学総合研究センター
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Abe Hideki
Department Of Chemistry The University Of Tokyo
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Hirayama J
Hokkaido Red Cross Blood Center
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Kamo Noki
Department Of Biophysical Chemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Kamo Naoki
Department Of Pharmaceutical Sciences Hokkaido University
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HIRAYAMA Junichi
Hokkaido Red Cross Blood Center
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HORIUCHI Motohiro
Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine
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SHINAGAWA Morikazu
Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine
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Ikebuchi Kenji
Department Of Hematology Nippon Medical School
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Shinagawa M
National Inst. Animal Health Ibaraki Jpn
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Shinagawa Morikazu
Department Of Hygiene And Microbiology Faculty Of Veterinary Medicine Hokkaido University
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Sekiguchi S
Hokkaido Red Cross Blood Center:center For Advanced Science And Technology Hokkaido University
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Sekiguchi Sadayoshi
Hokkaido Red Cross Blood Center
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Abe Hideki
Hokkaido Red Cross Blood Center
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Horiuchi Motohiro
Department Of Veterinary Public Health Obihiro University Of Agriculture And Veterinary Medicine
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Horiuchi Motohiro
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
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Ikebuchi Kenji
Hokkaido Red Cross Blood Center
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Horiuchi M
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Abe H
Department Of Chemistry The University Of Tokyo
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Inokuchi Koiti
Nippon Medical School Tokyo Jpn
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Kamo Naoki
Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University
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SHINAGAWA Morikazu
Department of Hygiene and Alicrobiology, Facultt of Veterinaiy Medicine, Hokkaido University
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