Synergistic Effect of Indomethacin with Adriamycin and Cisplatin on Tumor Growth
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概要
- 論文の詳細を見る
In this study, we have examined the antitumor effect of combined administrations of indomethacin(IND)with chemotherapeutic drugs on tumor growth. Colon 26 clone 20(C20)eells and monocyte chemotactant protein-1(MCP-1)transfected C20 cells(C20βA-2-1)were used and these cells were inoculated into the footpad of BALB/c mice. At day l after tumor inoculation, treatment with 0.001% IND via the drinking water was commenced. At days 4, 6, and 8, adriamycin or cisplatin was administered intravenously at a dose of 5mg/kg or intraperitoneally at a dose of 2 mg/kg, respectively. Although IND, adriamycin and cisplatin only partially reduced the growth of the C20 tumors after treatment with each drug on its own, a marked synergistic effect was observed when they were given in combination. A synergistic effect between IND and cisplatin on C20βA-2-1 was also observed. However, IND itself showed no suppression of C20βA-2-1 tumor growth. These results suggest that combination of indomethacin with chemotherapeutic drugs could be an effective form of cancer chemotherapy. The observed effects may be dependent on the expression of MCP-1.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
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Hattori K
Niigata Coll. Pharmacy Niigata Jpn
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Hattori Kaoru
新潟薬科大学 薬理
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Nakashima Emi
Department Of Pharmaceutics Kyoritsu University Of Pharmacy
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Nakashima Emi
Department Of Pediatrics:hospital Pharmacy:and Faculty Of Pharmaceutical Sciences University Of Kana
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Nakashima Emi
Department Of Pharmaceutics Kyoritsu College Of Pharmacy
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Matsushita Ryo
Department Of International Pharmacy And Health Sciences Graduate School Of Natural Science And Tech
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HATTORI Kenji
Department of Otolaryngology, Sumitomo Hospital
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ABE YOSHIHIRO
Department of Public Health, Yamagata University Graduate School of Medicine
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Hattori K
Tohoku Univ. Sendai Jpn
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KIMURA Kazuko
Department of International Pharmacy and Health Sciences, Graduate School of Natural Science and Tec
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Kimura K
Department Of International Pharmacy And Health Sciences Graduate School Of Natural Science And Tech
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Abe Yoshihiro
Department Of Fundamental Experimental Pharmaco-science Kyoritsu College Of Pharmacy
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Hattori Kenji
Department Of Otolaryngology Sumitomo Hospital
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HATTORI Kenji
Department of Material Physics, Faculty of Engineering Science, Osaka University
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Hattori Kaoru
Department of Pharmacology, Niigata College of Pharmacy
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