The Effects of Intracerebroventricular Administration of Adrenergic Agonists and Antagonists on Adrenaline Secretion from the Adrenal Medulla in Stressed Conscious Rats
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概要
- 論文の詳細を見る
The effects of intracerebroventricular (i. c. v.) administration of adrenergic agonists and antagonists on the increase in serum adrenaline (Ad) induced by immobilization stress were examined in unanesthetized, unrestrained rats. The serum Ad of rats showed a significant linear increase as time elapsed after the induction of immobilization stress. This immobilization stress-induced increase was inhibited by the i. c.v. administration of a small amount of noradrenaline (NA) and phenylephrine. Isoproterinol and clonidine failed to inhibit the immobilization stress-induced increase. The inhibition of the immobilization stress-induced increase by i. c.v. administration of NA was antagonized by pretreatment with phentolamine and prazosin, but not by pretreatment with yohimbine and propranolol. These results suggested that NA administered via an i. c. v. route may inhibit the stress-induced increase in adrenomedullary Ad secretion by an action on the central α_1-adrenoceptor.
- 公益社団法人日本薬学会の論文
著者
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NAKAMURA Mikio
Department of Chemistry, School of Medicine, Toho University
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Inaba Minoru
Department Of Energy And Hydrocarbon Chemistry Graduate School Of Engineering Kyoto University
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Inaba M
Kyorin Univ. Tokyo Jpn
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KAMATA Kunie
Department of Pharmacology, Kyorin University School of Medicine
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INOUE Hakubun
Department of Pharmacology, Department of Psychoneurology, Department of Urology, Kyorin University
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MATSUYAMA Kyosuke
Department of Pharmacology, Department of Psychoneurology, Department of Urology, Kyorin University
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Nakamura Mikio
Department Of Pharmacology Department Of Psychoneurology Department Of Urology Kyorin University Sch
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Nakamura Mikio
Department Of Anatomy Jikei-kai School Of Medicine
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Kamata K
Department Of Pharmacology Department Of Psychoneurology Department Of Urology Kyorin University Sch
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Inoue H
Department Of Pharmacology Department Of Psychoneurology Department Of Urology Kyorin University Sch
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Matsuyama Kyosuke
Department Of Pharmacology Department Of Psychoneurology Department Of Urology Kyorin University Sch
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KAMATA Kunie
Department of Pharmacology, Department of Psychoneurology, Department of Urology, Kyorin University School of Medicine
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INABA Minoru
Department of Applied Chemistry, Graduate School of Engineering, Doshisha University
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