1,2,4-Triazoles. VII. Methylation of 1,2,4-Triazoles
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概要
- 論文の詳細を見る
The methylations of twenty-five 1,2,4-triazoles with methyl iodide and diazomethane were studied and substituent effects on the product ratios are discussed. Methylation of 1,2,4-triazole and its symmetrically 3,5-disubstituted derivatives occurred almost exclusively at the 1-position. These results are interpreted in terms of the α-effect of the α-diaza structures of the 1- and 2-positions in the 1,2,4-triazoles. Methylations of 3-substituted 1,2,4-triazoles with methyl iodide and diazomethane occurred preferentially at the N-1 atom, which is sterically less hindered. However, methylation of 3-α-pyridyl-1,2,4-triazole with diazomethane occurred preferentially at the N-2 atom next to the α-pyridyl group due to the particular space effect of the α-pyridyl group. Methylation of 3,5-disubstituted 1,2,4-triazoles occurred predominantly at the vicinal nitrogen atom next to the electron-releasing group, but 3-α-pyridyl derivatives were methylated mainly at the vicinal nitrogen atom next to the α-pyridyl group.
- 公益社団法人日本薬学会の論文
- 1976-12-25
著者
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久保田 晴寿
Faculty of Pharmaceutical Sciences, University of Tokushima
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宇多 正行
Faculty of Pharmaceutical Sciences, University of Tokushima
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久保田 晴寿
徳島大学薬学部
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久保田 晴寿
Faculty Of Pharmaceutical Sciences University Of Tokushima
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宇多 正行
Faculty Of Pharmaceutical Sciences University Of Tokushima
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佐藤 耕治
Faculty of Pharmaceutical Sciences, University of Tokushima
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久積 行徳
Faculty of Pharmaceutical Sciences, University of Tokushima
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佐藤 耕治
Faculty Of Pharmaceutical Sciences University Of Tokushima
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久積 行徳
Faculty Of Pharmaceutical Sciences University Of Tokushima
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