Synthesis of Novel Dihydro-1,2,4-triazoles from Thiosemicarbozones via 1,4-Diacetyl-3-methylsulfonyl-4,5-dihydro-1H-1,2,4-triazoles as Key Intermediates
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概要
- 論文の詳細を見る
Novel 3,5-disubstituted 4,5-dihydro-1H-1,2,4-triazoles were synthesized by nucleophilic substitution of 1,4-diacetyl-3-methylsulfonyl-4,5-dihydro-1H-1,2,4-triazoles (15a-c), which were obtained by oxidation of 1,4-diacetyl-3-methylthio-4,5-dihydro-1H-1,2,4-triazoles (5a-c) with 2 mol eq of m-chloroperbenzoic acid. Acetylation of aldehyde or ketone S-methylisothiosemicarbazones (3a-c) with acetic anhydride at room temperature gave aldehyde or ketone 4-acetyl-3-methyl-isothiosemicarbazones (4a-c), which cyclized with acetic anhydride under heating to give 5a-c. Compounds 5a-c were also obtained by the reaction of 3a-c with acetic anhydride under heating.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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豊岡 康平
Faculty of Pharmaceutical Sciences, University of Tokushima
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久保田 晴寿
Faculty of Pharmaceutical Sciences, University of Tokushima
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久保田 晴寿
徳島大学薬学部
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豊岡 康平
Faculty Of Pharmaceutical Sciences University Of Tokushima
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久保田 晴寿
Faculty Of Pharmaceutical Sciences University Of Tokushima
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