1,2,4-Triazoles. I. Methylation of 3-α-Pyridyl-1,2,4-triazoline-5-thione
スポンサーリンク
概要
- 論文の詳細を見る
Methylation of 3-α-pyridyl-1,2,4-triazoline-5-thione (II) with methyl iodide in alkaline solution gave 5-methylthio-3-α-pyridyl-1,2,4-triazole (III) and its N-methyl derivatives, 1-, 2-, and 4-methyl-5-methylthio-3-α-pyridyl-1,2,4-trizaole (IV, V and VI). The structures of these compounds were established by elemental analysis, spectral data and the identification with the compounds prepared by different methods. IV, V and VI were also produced by methylation of III with methyl iodide in alkaline solution. Methylation of III with dimethyl sulfate in alkaline solution or diazomethane in methanol also gave the same products. The ratios of the amount of IV : V : VI in the products were determined by nuclear magnetic resonance spectroscopy and it was found that IV was predominantly formed in every case.
- 公益社団法人日本薬学会の論文
- 1971-11-25
著者
-
久保田 晴寿
Faculty of Pharmaceutical Sciences, University of Tokushima
-
久保田 晴寿
Faculty Of Pharmaceutical Sciences University Of Tokushima
-
宇田 正行
Faculty of Pharmaceutical Sciences, University of Tokushima
-
大塚 通子
Faculty of Pharmaceutical Sciences, University of Tokushima
-
宇田 正行
Faculty Of Pharmaceutical Sciences University Of Tokushima
-
大塚 通子
Faculty Of Pharmaceutical Sciences University Of Tokushima
関連論文
- Synthesis of 2-Substituted 1,3,4-Thiadiazol-5-ylacetic, Propionic, and Gltaric Acids
- Synthesis and Absolute Configuration of Optically Active 2,3-Disubstituted 2,3-Dihydro-1,3,4-thiadiazoles
- Synthesis and Uncoupling Activities of Hydrophobic Thioureas
- Synthesis of 3-Acylamino-4-hydroxymethyl-2-oxo-1-sulfoazetidines and Related Compounds
- Phenolic Components from Leaf Oil of Illicium anisatum L.
- Effect of 2,4-Dihydro-3H-1,2,4-triazole-3-thiones and Thiosemicarbazones on Iodide Uptake by the Mouse Thyroid : the Relationship between Their Structure and Anti-thyroid Activity
- 8-キノリンスルホニルクロライドとヒドラジンの反応
- オクテット
- 中日天然薬物研討会
- 2-シアノピリジンとヒドラジンの反応について
- Studies on the Synthesis of 1,3,4-Thiadiazole Derivatives. II. Synthesis of 1,3,4-Thiadiazoline-5-thiones from Amidrazones and Carbon Disulfide
- オクテット
- Synthesis of Novel Dihydro-1,2,4-triazoles from Thiosemicarbozones via 1,4-Diacetyl-3-methylsulfonyl-4,5-dihydro-1H-1,2,4-triazoles as Key Intermediates
- Synthesis of 2-Substituted 5-(1-Oxido-4-pyridyl)- and 5-(1-Oxido-2-pyridyl)-1,3,4-thiadiazole Derivatives by Substitution of 2-Methylsulfonyl Group with Various Nucleophiles(Organic,Chemical)
- 1,2,4-Triazoles. VIII. Synthesis and Antimicrobial Activity of 3-Alkylthio-5-pyridyl-1,2,4-triazoles and Related Compounds
- 1,2,4-Triazoles. VII. Methylation of 1,2,4-Triazoles
- 1,2,4-Triazoles. VI. Methylation of 3-Phenyl-1,2,4-triazolin-5-one, 3-Phenyl-1,2,4-triazoline-5-thione, and Their Monomethylated Derivatives
- 1,2,4-Triazoles. IV. Tautomerism of 3,5-Disubstituted 1,2,4-Triazoles
- 1,2,4-Triazoles. III. The Tautomerism of 3-Phenyl-1,2,4-triazolin-5-one, 3-Phenyl-1,2,4-triazoline-5-thione and Their N-Methyl Derivatives
- 1,2,4-Triazoles. II. The Tautomerism of 3-α-Pyridyl-1,2,4-triazoline-5-thione and Its Methyl Derivatives
- 1,2,4-Triazoles. I. Methylation of 3-α-Pyridyl-1,2,4-triazoline-5-thione