1,3,4-Thiadiazole誘導体の合成研究(第1報) : Pyridyl-1,3,4-thiadiazole誘導体の合成について
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概要
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2-Alkylthio-5-(2-pyridyl)-1,3,4-thiadiazoles (R : CH_3-C_4H_9) and 2-alkylthio-5-(3-pyridyl)-1,2,4-thiadiazoles (R : CH_3,C_2H_5) were synthesized by cyclization of the corresponding alkyl 3-aroyldithiocarbazates with concentrated sulfuric acid. Oxidation of 2-alkylthio-5-pyridyl-1,3,4-thiadiazoles with potassium permanganate gave the corresponding 2-alkylsulfonyl-5-pyridyl-1,3,4-thiadiazoles. It was found that the cyclization product of potassium 3-picolinoyl dithiocarbazate with concentrated sulfuric acid is mainly 2-pyridyl-1,3,4-thiadiazolin-5-thione rather than the thiol compound, by comparing the ultraviolet absorption spectra of the compound with those of N-and S-methyl derivatives which were obtained by methylation of the product with diazomethane.
- 公益社団法人日本薬学会の論文
- 1970-07-25
著者
関連論文
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- 1,3,4-Thiadiazole誘導体の合成研究(第1報) : Pyridyl-1,3,4-thiadiazole誘導体の合成について
- オクテット
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