A Screening Procedure for the Formation of Nitroso Derivatives and Mutagens by Drug-Nitrite Interaction
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概要
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A general procedure for screening for the formation of nitroso derivatives and/or mutagens by drug-nitrite interaction was established. A test drug (50 mM) was reacted with nitrite (500 mM) at pH 3.0-3.5 and 37℃ for 4 h. The residual nitrite in the reaction mixture was decomposed with ammonium sulfamate. The nitrite-free reaction mixture was assayed for both nitroso derivatives and mutagens by colorimetry of Griess reagentpositive substances formed by treatment with hydrogen bromide and by mutagenesis assay using Salmonella typhimurium TA98 and TA100 as tester strains, respectively.
- 社団法人日本薬学会の論文
- 1982-09-25
著者
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武田 寧
National Institute of Hygienic Sciences
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武田 寧
Hatano Research Institute, Food and Drug Safety Center
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金谷 浩子
Hatano Research Institute, Food and Drug Safety Center
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金谷 浩子
Hatano Research Institute Food And Drug Safety Center
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