Norrish Type I Cleavage of 9-Oxabicyclo[3.3.1]nonan-3-one : A Straightforward Synthesis of (±)-(cis-6-Methyletrahydropyran-2-yl)acetic Acid, a Constituent of Civet

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概要

• 論文の詳細を見る

• The photo-reaction of 9-oxabicyclo[3.3.1]nonan-3-one (2) was investigated. Upon irradiation in methanol, the ketone (2) predominantly gave the methanol adduct, 3-hydroxymethyl-9-oxabicyclo[3.3.1]nonan-3-ol (3), accompanied with photo-reduced products, exo- and endo-9-oxabicyclo[3.3.1]nonan-3-ol (4 and 5). Irradiation in water resulted in Norrish type I cleavage to give directly (cis-6-methyletrahydropyran-2-yl)acetic acid (1), a constituent of civet, in moderate yield.

• 社団法人日本薬学会の論文
• 1995-03-15

著者

• 田辺 元三

  近畿大学薬学部

• 村岡 修

  Faculty of Pharmaceutical Sciences, Kinki University

• 田辺 元三

  Faculty of Pharmaceutical Sciences, Kinki University

• 前田 知美

  Faculty Of Pharmaceutical Sciences Kinki University

• 村岡 修

  Faculty Of Pharmaceutical Sciences Kinki University

• 田邉 元三

  近畿大薬

• 奥村 正文

  Faculty of Pharmaceutical Sciences, Kinki University

• 王 礼[チン]

  Divison of Organic Chemistry, China Pharmaceutical University

• 奥村 正文

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 王 礼

  National Univ. Singapore Sgp

• 村岡 修

  近畿大薬:近畿大薬総研

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