Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing

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概要

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• Extracts from the leaves of Chromolaena odorata have been shown to be beneficial for treatment of wounds. The crude ethanol extract of the plant had been demonstrated to be a powerful antioxidant to protect fibroblasts and keratinocytes in vitro. In this study, the most active compounds were fractionated and identified from the crude extract using liquid chromatography coupled with UV spectroscopy and mass spcctrometry. The antioxidant effects of purified fractions on cultured fibroblasts and keratinocytes were investigated using colorimetric and lactate hydrogenase release assay. The results showed that the phenolic acids present(protocatechuic, p-hydroxybenzoic, p-coumaric, ferulic and vanillic acids)and complex mixtures of lipophilic flavonoid aglyeones(flavanones, flavonols, flavones and chalcones)were major and powerful antioxidants to pnotect cultured skin cells against oxidative damage. In conclusion, the extract from C. odorata contains a mixture of powerful antioxidant compounds that may be one ofpotential mechanism contributing to enhanced wound healing.

• 公益社団法人日本薬学会の論文
• 2001-12-01

著者

• Lee Seng

  Department Of Plastic Surgery Singapore General Hospital And Department Of Pharmacy Royal Botanic Ga

• Lee Seng

  Department Of Chemistry And Chemistry Institute For Functional Materials Pusan National University

• Chan Sui-yung

  Department Of Pharmacy National Unversity Of Singapore Royal Botanic Gardens

• Phan Toan-thang

  Department Of Plastic Surgery Singapore General Hospital And Department Of Pharmacy Royal Botanic Ga

• Wang Lingzhi

  Department Of Pharmacy National University Of Singapore Royal Botanic Gardens

• 王 礼

  National Univ. Singapore Sgp

• SEE Patrick

  Department of Plastic Surgery, Singapore General Hospital and Department of Pharmacy, Royal Botanic

• GRAYER Renee

  Republic of Singapore, and Jodrell Laboratory, Royal Botanic Gardens

• Grayer Renee

  Republic Of Singapore And Jodrell Laboratory Royal Botanic Gardens

• See Patrick

  Department Of Plastic Surgery Singapore General Hospital And Department Of Pharmacy Royal Botanic Ga

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