CONFORMATIONAL STUDIES OF CYCLO(L-Phe-L-Pro-Gly-L-Pro)_2 BY ^<13>C NUCLEAR MAGNETIC RESONANCE

概要

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The ^<13>C-NMR spectrum (Fig. 2,1) of cyclooctapeptide cyclo(L-Phe-L-Pro-Gly-L-Pro)_2 (A) in CDCL_3 suggested that its conformation involved the coexistence of two kinds of C_2-symmetric conformation with trans-trans-trans-trans and cis-trans-trans-trans forms. Adding 0.5 equivalent of CsSCN or one equivalent of DL-Phe-One・HCl to the solution of cyclopeptide (A) in CDCl_3 yielded ^<13>C-NMR spectra (Fig. 2,2 and Table I) which suggested a single C_2-symmetric conformation with trans-trans-trans-trans form, resulting from the formation of complexes with CsSCN or DL-Phe-One・HCl. The ^<13>C-NMR spectrum of complexes of A with DL-Phe-OMe・HCl displayed separete resonances^<2)> for C_γ, C_o, ^<1)> Cm, ^<1)> C_α, and C_β of D-Phe-OMe・HCl and L-Phe-OMe・HCl (Table I).
公益社団法人日本薬学会の論文
1991-06-25