A Putative Mouse Oocyte Maturation Inhibitory Protein from Urine of Pregnant Women : N-Terminal Sequence Homology with Human Nonsecretory Ribonuclease

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概要

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• A putative mouse oocyte maturation inhibitory protein was purified from a urine preparation from pregnant women by Sephadex G-100 gel filtration and reverse-phase chromatography on the basis of inhibitory activity of polar body formation of denuded mouse oocytes in culture. Amino terminal sequence analyses showed that residues 5 to 15 of this protein were identical to residues 1 to 11 of human nonsecretory ribonuclease. Furthermore, residues 1 to 4 of this protein were identical to residues -4 to -1,corresponding to part of a signal peptide region of eosinophil-derived neurotoxin, whose mature sequence is identical to nonsecretory ribonuclease. These results indicate that the protein purified as a putative mouse oocyte maturation inhibitory protein from the urine of pregnant women may be a product of an peculiar processing of a nonsecretory ribonuclease precursor.

• 公益社団法人日本薬学会の論文
• 1991-01-25

著者

• 榊原 隆三

  長崎大・薬

• 石黒 正恒

  Department of Biochemistry, School of Clinical Pharmaceutical Sciences, Nagasaki University

• 榊原 隆三

  Department of Biochemistry, School of Clinical Pharmaceutical Sciences, Nagasaki University

• 石黒 正恒

  長崎大学薬学部

• 冨永 伸明

  長崎大・薬

• 冨永 伸明

  Department of Biochemistry, School of Clinical Pharmaceutical Sciences, Nagasaki University

• 佐藤 英明

  Department Of Animal Science Faculty Of Agriculture Kyoto University

• 石黒 正恒

  Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University

• 橋田 佳代

  Department of Biochemistry, School of Pharmaceutical Sciences, Nagasaki University

• 坂井 一也

  Department of Biochemistry, School of Pharmaceutical Sciences, Nagasaki University

• 今村 定臣

  Imamura Women's Hospital

• 大松 冨美子

  Imamura Women's Hospital

• 今村 定臣

  Imamura Women's Hospital

• 大松 冨美子

  Imamura Women's Hospital

• 橋田 佳代

  Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University

• 坂井 一也

  Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University

• Ishiguro Masatsune

  Department Of Biochemistry School Of Clinical Pharmaceutical Sciences Nagasaki University

• Ishiguro Masatsune

  Department Of Biochemistry School Of Clinical Pharmaceutical Science Nagasaki University

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