Effects of Ricin, a Protein Toxin, on Glucose Absorption by Rat Small Intestine. (Biochemical Studies on Oral Toxicity of Ricin. II)
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概要
- 論文の詳細を見る
The effects of ricin, a proteinous toxin from castor bean seeds, on glucose absorption by rat small intestine have been examined by the everted sac method. Glucose absorption was affected by ricin poisoning at 1 h after oral administration, and the inhibition reached the maximum at 5h, whereas very slight impairment of glucose absorption was observed at 5h after intraperitoneal injection of ricin. The dose required for 50% impairment of glucose absorption was 10mg ricin/kg body weight of rat when determined at 5 h after oral administration. This inhibition of glucose absorption was found only when ricin or ricin B-chain had been in contact with the mucosal membrane of the small intestine of the normal rats. The inhibition was prevented by the presence of a galactose-containing sugar, lactose. The effect of ricin on glucose absorption under physiological conditions was analyzed in situ, and the increase in blood glucose level was inhibited in ricin-intoxicated rats. These results suggest that ricin, especially its B-chain, interacts primarily with the intestinal mucosa and inhibits sugar absorption of the rat small intestine. It was also inferred that ricin B-chain is cytotoxic to the epithelial absorptive cells of the small intestine, but that impairment of sugar absorption by the small intestine alone is not the direct cause of death of animals following oral administration of ricin.
- 社団法人日本薬学会の論文
- 1984-08-25
著者
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石黒 正恒
Department of Biochemistry, School of Clinical Pharmaceutical Sciences, Nagasaki University
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関根 一郎
Department of Pathology, The Atomic Disease Institute, School of Medicine, Nagasaki University
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市来 修
長崎大学薬学部
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石黒 正恒
長崎大学薬学部
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原田 博道
長崎大学薬学部
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菊谷 元資
福山大学薬学部
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原田 博道
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Nagasaki University
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市来 修
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Nagasaki University
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西森 一正
Department of Pathology, Atomic Disease Institute, School of Medicine, Nagasaki University
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菊谷 元資
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Nagasaki University
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関根 一郎
Department Of Pathology The Atomic Disease Institute School Of Medicine Nagasaki University
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石黒 正恒
Department Of Biochemistry School Of Pharmaceutical Sciences Nagasaki University
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西森 一正
長崎大学医学部
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西森 一正
Department Of Pathology Atomic Disease Institute Nagasaki University School Of Medicine
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Ishiguro Masatsune
Department Of Biochemistry School Of Clinical Pharmaceutical Sciences Nagasaki University
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Ishiguro Masatsune
Department Of Biochemistry School Of Clinical Pharmaceutical Science Nagasaki University
関連論文
- Biochemical Studies on Oral Toxicity of Racin. V. The Role of Lectin Activity in the Intestinal Absorption of Ricin
- リシン(Ricin)の経口毒性に関する生化学的研究 : II. ラット小腸におけるグルコース吸収に及ぼすタンパク質毒素リシンの影響(発表論文抄録(1984年),福山大学開学10周年記念号)
- Effects of Ricin, a Protein Toxin, on Glucose Absorption by Rat Small Intestine. (Biochemical Studies on Oral Toxicity of Ricin. II)
- Steroidogenic Activity of Synthetic Hybrid Molecules Composed of Human Chorionic Gonadotropin and Either the A or B Chain of Lectin Ricin or Horseradish Peroxidase
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- Effective Purification of Human Chorionic Gonadotropin and Its Subunits From Pregnant Women's Urinary Peptides Adsorbed on Reverse-Phase Resin
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- The Binding of Ricin to Its Receptor Is Not Required for the Expression of Its Toxicity
- リシン(Ricin)の経口投与によるラット小腸の粘膜変化に関する病理学的研究 : I. 顕微鏡的所見(1986年発行分)
- Biochemical Studies on Oral Toxicity of Ricin. I. Ricin Administered Orally Can Impair Sugar Absorption by Rat Small Intestine
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- Biochemical Studies on Oral Toxicity of Ricin. IV. A Fate of Orally Administered Ricin in Rats
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