Anti-ulcer Effects of Trichosanthes Fruits

概要

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Anti-ulcer activities of fruits of Trichosanthes kirilowii MAXIMOQWICZ var. japonica KITAMURA (50% ethanolic extract, TKE) were investigated in rats.TKE, at doses of 100-1000mg/kg, showed potent protection against experimental gastric lesions, namely, those induced by water-immersion, histamine, serotonin, HCl・ethanol, 0.6N HCl, 0.2N NaOH, 35% NaCl, and Shay' ulcer and acetic acid-induced gastric ulcer.At doses of 500-1000mg/kg, TKE decreased the gastric secretion and acid output in pylorus-ligation (for 7h), but 100mg/kg of TKE had no influence on the gastric secretion. On the other hand, TKE exerted inhibition on the contractile responses of the isolated ileum of mouse to acetylcholine.These results suggested that TKE has an anti-ulcer effect.
社団法人日本薬学会の論文
1990-05-25