Marble burying testにおける柴胡加龍骨牡蛎湯の影響

概要

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The effect of Saiko-ka-ryukotsu-borei-to (SRBT) on the alteration of Marble burying test was investigated in mice. SRBT (100 and 300 mg/kg, p.o.) inhibited the behavior of mice dose-dependently as clomipramine (30 mg/kg, p.o.) and diazepam (3 mg/kg, p.o.). The Marble burying behavior is known to be affected by alteration of spontaneous locomotor activity, but SRBT did not affect on the activity at the doses tested. Videocamera system analysis demonstrated that clomipramine strongly inhibited the burying behavior and caused the intense freezing behavior, that SRBT and diazepam did not inhibit the burying behavior so effectively as clomipramine but that these drugs did not cause the freezing behavior. These results indicated that SRBT might be more advantageous in the clinical use than clomipramine as the adverse reaction, such as serotonin syndrome, of SRBT should be much less.
日本生薬学会の論文
2000-06-20