Characterization of Powder-Coated Microsponge Prepared by Dry Impact Blending Method

概要

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A novel powder particle, nominated as powder-coated microsponge (PMS) containing sunset yellow (SY), was prepared by dry impact blending, and the subsequent dissolution behavior of SY from PMS was studied. Two kinds of spherical and porous cellulose particles known as microsponge (10.3 or 53.9 μm in volume-surface mean diameter) containing SY were coated with spherical polymethylmethacrylate particles (PMMA, 0.15 or 0.40 μm in diameter) and titanium dioxide particles (anatase-type, 0.25 μm in diameter). This coating was carried out without solvents. The angle of repose and the bulkiness of PMS were largely dependent on the amount of PMMA. The dissolution rate of SY from PMS decreased greatly as the amount of PMMA was increased, and was also influenced by the particle size of the microsponges and PMMA, but its correlation with the coating amount of titanium dioxide was very poor. On the basis of these results, a novel preparation of a micron-order offering a controllable release of ingredients is proposed.
公益社団法人日本薬学会の論文
1989-12-25